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Mike Liang is a Ph.D. candidate in the Biomedical Informatics Program at Stanford University. Liang received a B.S. in Computer Science with a minor in Chemistry at University of California San Diego. His research interests lie primarily in annotating likely functional sites in protein structures. His current research project with Dr. Russ Altman (pubmed) and Dr. Doug Brutlag is on automatic identification of conserved physicochemical properties around functional sites in 3D structures of proteins.

Web Projects

WebFEATURE - Web server for predicting functional sites on protein structures

Picture Gallery

Images generated by PyMOL or Chimera

Utilities

  • webload.py - PyMOL 0.96 plugin command extension for fetching PDB structures via the web
  • marker.py - PyMOL 0.96 plugin command extension for adding a spherical 'marker' at a given location
  • viewhits.py - PyMOL 0.96 plugin command extension for viewing WebFEATURE hits
  • histogram - flexible command line script written in Python to perform binning of numeric values (requires Numeric)

Publications

  • Liang MP, Banatao DR, Klein TE, Brutlag DL, and Altman RB. "WebFEATURE: an interactive web tool for identifying and visualizing functional sites on macromolecular structures." Nucleic Acids Research. (2003) Jul 1;31(13):3324-7. [PMID: 12824318]
  • Liang MP, Brutlag DL, and Altman RB. "Automated construction of structural motifs for predicting functional sites on protein structures." Pacific Symposium on Biocomputing. (2003);8:204-15. [PMID: 12603029]
  • Liang MP, Troyanskaya OG, Laederach A, Brutlag DL, and Altman RB. "Computational Functional Genomics." IEEE Signal Processing Magazine. (2004) Nov;21(6):62-69.
  • Liang MP. "Integrating Sequence and Structure Data for Identifying Functional Sites on Protein Structures." Stanford University Doctoral Dissertation. (2005) May.
  • Mooney SD, Liang MH, DeConde R, and Altman RB. "Structural characterization of proteins using residue environments." Proteins. (2005) Dec 1;61(4):741-7. [PMID: 16245324]
  • Liang MP, Brutlag DL, and Altman RB. "Integrating sequence and structure information for identifying serine protease active sites." (Under submission)
  • Liang MP, Brutlag DL, and Altman RB. "A structural library of protein functional sites." (In preparation)
  • Pubmed

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